Αποστολέας Θέμα: Common Antibiotics Cause Arrhythmias, Death And Everything Else  (Αναγνώστηκε 527 φορές)

Rose

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Common Antibiotics Cause Arrhythmias, Death And Everything Else
« στις: Μάρτιος 14, 2017, 00:25:43 »
https://www.forbes.com/sites/judystone/2015/11/09/common-antibiotics-cause-arrhythmias-death-and-everything-else/#48ead2d7d170

Common Antibiotics Cause Arrhythmias, Death And Everything Else

Shocking news—unless you are a physician or know healthcare—that commonly used antibiotics can cause death!

This time, the villains are macrolide antibiotics— Azit hromycin (Zithro max), Clarithromycin (Biaxin), and Erythromycin.

In a large meta-analysis, studies involving 20,779,963 participants were analyzed. The authors analyzed risk of death from any cause, as well as sudden cardiac death, to compensate for the survival benefit (improved survival) of the antibiotics in treating pneumonia. The findings? Macrolide antibiotics caused an additional 36 sudden cardiac deaths per million treatment courses. So about 1:8,500 patients will develop a serious arrhythmia, or irregular heartbeat, and 1:30,000 would die because of the antibiotics.

This shouldn’t come as a great surprise. We’ve long known that a number of medicines cause serious arrhythmias, often due to “QT prolongation.” So does hypokalemia (low potassium), hypomagnesia (low magnesium), which are often found in acutely ill patients, and certain other heart drugs. In comparisons, pen icillin and amox icillin did not have these side effects. With pen icillins, severe allergic reactions are the major risk. According to UpToDate, “Pen icillin-induced anaphylaxis [shock] occurs with an incidence of between one and four episodes per 10,000 administrations,” with an estimated 500-1000 deaths each year in the U.S.

Azit hromycin (Zithro max or Z-pak, Pfizer) was the 8th most prescribed drug, and the best selling antibiotic here in 2012, with 56.2 million prescriptions in the U.S. alone.

And azit hromycin itself already achieved a warning from the FDA in 2012 regarding the risk of QT prolongations and a rare associated arrhythmia called torsades de pointes. Interestingly, women are at inherently higher risk for torsades, highlighting why we need more women in clinical trials, although they have historically been excluded. What this study by Dr. Yun-Jiu Cheng and colleagues adds is better quantifying the cardiac risks of macrolides, answering, “how small is small?”

It’s not only macrolide antibiotics that are associated with heart arrhythmias: quinolone antibiotics, including the widely prescribed Levaquin and Cipro have had their own share of cardiac problems, and grepafloxacin was withdrawn from the market shortly after its release. Several antipsychotic meds including Haldol, antidepressants, anticancer drugs, and Diflucan (fluconazole) among others, are also associated with prolonged QT. Prolonged QT killed terfenadine (Seldane), a lucrative, nonsedating antihistamine, which was the first in its class, and cisapride (Propulsid), a popular GI drug.

(το υπόλοιπο θα το διαβάσετε από το σύνδεσμο, υπάρχει τεχνικό πρόβλημα μεταφοράς του κειμένου)
« Τελευταία τροποποίηση: Μάρτιος 14, 2017, 00:43:36 από Rose »
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Rose

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Απ: Common Antibiotics Cause Arrhythmias, Death And Everything Else
« Απάντηση #1 στις: Μάρτιος 14, 2017, 00:47:18 »
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0735109715062968?returnurl=http:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0735109715062968%3Fshowall%3Dtrue&referrer=https:%2F%2Fwww.forbes.com%2F

The Role of Macrolide Antibiotics in Increasing Cardiovascular Risk

Abstract

Large cohort studies provide conflicting evidence regarding the potential for oral macrolide antibiotics to increase the risk of serious cardiac events.

Objectives

This study performed a meta-analysis to examine the link between macrolides and risk of sudden cardiac death (SCD) or ventricular tachyarrhythmias (VTA), cardiovascular death, and death from any cause.

Methods

We performed a search of published reports by using MEDLINE (January 1, 1966, to April 30, 2015) and EMBASE (January 1, 1980, to April 30, 2015) with no restrictions. Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the associations of interest were included.

Conclusions

Administration of macrolide antibiotics is associated with increased risk for SCD or VTA and cardiovascular death but not increased all-cause mortality.
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Απ: Common Antibiotics Cause Arrhythmias, Death And Everything Else
« Απάντηση #2 στις: Μάρτιος 14, 2017, 00:49:43 »
https://www.fda.gov/Drugs/DrugSafety/ucm341822.htm

FDA Drug Safety Communication: Azithro mycin (Zithro max or Zmax) and the risk of potentially fatal heart rhythms

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